Succinate Transport inEscherichia coliMutants Defective in Succinate Metabolism
نویسندگان
چکیده
منابع مشابه
Focally perfused succinate potentiates brain metabolism in head injury patients
Following traumatic brain injury, complex cerebral energy perturbations occur. Correlating with unfavourable outcome, high brain extracellular lactate/pyruvate ratio suggests hypoxic metabolism and/or mitochondrial dysfunction. We investigated whether focal administration of succinate, a tricarboxylic acid cycle intermediate interacting directly with the mitochondrial electron transport chain, ...
متن کاملGlucose-induced crypticity toward succinate metabolism in Saccharomyces lactis.
Saccharomyces lactis grown on glucose adapted very slowly to growth on succinate. This initial inability of glucose-grown cells to grow on succinate was paralleled by their inability to oxidize succinate. The possibility that repression by glucose of respiratory chain components was responsible for these observations was examined. Glucose-grown cells were able to respire glucose, ethyl alcohol,...
متن کاملCitrate and succinate transport in proximal tubule cells.
Urinary citrate, which inhibits calcium nephrolithiasis, is determined by proximal reabsorption via an apical dicarboxylate transporter. Citrate is predominantly trivalent at physiological pH, but citrate(-2) is transported at the apical membrane. We now demonstrate that low-Ca solutions induce transport of citrate(-2) and succinate in opossum kidney cells. With 1.2 mM extracellular Ca, citrate...
متن کاملSuccinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Myocardial ischaemia/reperfusion (IR) injury is a major cause of death worldwide and remains a disease for which current clinical therapies are strikingly deficient. While the production of mitochondrial reactive oxygen species (ROS) is a critical driver of tissue damage upon reperfusion, the precise mechanisms underlying ROS production have remained elusive. More recently, it has been demonstr...
متن کاملInvestigation of Hepatic Metabolism of DNP Hyperpolarized 1,4-C2 Succinate
Introduction: Succinic acid, containing two equivalent carboxylic acid carbons, is a prime molecule for use in hyperpolarization studies. Hyperpolarized succinate has many potential uses as it has been implicated as a paracrine signal for liver damage [1] and succinate dehydrogenase (SDH) has been shown to be a tumor suppressor [2]. Mutations in the SDH enzyme lead to accumulation of intracellu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1972
ISSN: 0002-1369
DOI: 10.1080/00021369.1972.10860571